Quinolines and derivatives
MEDCHEMEXPRESS LLC 1-tert-Butyl-3-ethoxybenzene | 133073-81-1 | 95.0% | C12H18O | 250 MG
1-tert-Butyl-3-ethoxybenzene is a drug intermediate used for the synthesis of various active compounds. It is for research use only.
- Molecular weight: 178.28
- Appearance: Liquid
- Color: Light yellow to light brown
MEDCHEMEXPRESS LLC Temsirolimus | 162635-04-3 | C56H87NO16 | 200MG
Temsirolimus is an inhibitor of mTOR with an IC50 of 1.76 μM. It activates autophagy and prevents deterioration of cardiac function in animal models. This product is an analytical standard intended for research and analytical applications.
- Inhibits mTOR kinase activity
- Activates autophagy
- Prevents deterioration of cardiac function
- Induces apoptosis in primary human lymphoblastic leukemia (ALL) cells
- Delays growth of xenografts
- Improves performance on behavioral tasks in Huntington disease models
MEDCHEMEXPRESS LLC Ipragliflozin L-Proline | 951382-34-6 | 99.9% | 519.58 | 200 MG
Ipragliflozin (L-Proline) is a highly potent and selective SGLT2 inhibitor with an IC50 of 2.8 nM, showing little to no potency for SGLT1/3/4/5/6. It is intended for research use only.
- Potently and selectively inhibits human, rat, and mouse SGLT2.
- Exhibits stability against intestinal glucosidases.
- Shows good pharmacokinetic properties following oral dosing.
- Dose-dependently increases urinary glucose excretion.
- Reduces blood glucose and plasma insulin levels.
- Improves glucose intolerance.
MEDCHEMEXPRESS LLC (S,R,S)-AHPC-amido-C7-acid | 2172819-76-8 | 98.7% | 600.77 | 100 MG
(S,R,S)-AHPC-amido-C7-acid incorporates a VHL ligand for the E3 ubiquitin ligase and a PROTAC linker, making it suitable for designing PROTACs. It is for research use only.
- Incorporates a VHL ligand for E3 ubiquitin ligase
- Includes a PROTAC linker
- Suitable for designing PROTACs
- Purity of 98.71%
- Molecular weight of 600.77
- Appears as a solid
- Color is white to off-white
- Relevant to cancer research and targeted therapy
MEDCHEMEXPRESS LLC HSGN-94 | 2570797-85-0 | 508.51 | 50 MG
HSGN-94 is a potent antimicrobial agent with lipoteichoic acid (LTA) biosynthesis inhibition. HSGN-94 inhibits drug-resistant Gram-positive bacteria with MIC values of 0.25-2 μg/mL. HSGN-94 inhibits biofilm formation of MRSA and Vancomycin-resistant Enterococci. HSGN-94 also inhibits pro-inflammatory cytokines, exhibits in vivo efficacy in an MRSA murine wound infection model.
- Potent antimicrobial agent with LTA biosynthesis inhibition.
- Inhibits drug-resistant Gram-positive bacteria with MIC values of 0.25-2 μg/mL.
- Inhibits biofilm formation in MRSA and Vancomycin-resistant Enterococci.
- Inhibits pro-inflammatory cytokines.
- Directly binds to PgsA.
- Downregulates the expression level of PgsA, an essential protein for phospholipid synthesis.
MEDCHEMEXPRESS LLC Lobeglitazone (sulfate) | 763108-62-9 | 99.6% | 578.61 | 25 MG
Lobeglitazone sulfate is a new type of thiazolidinedione, acting as an orally active agonist for PPARγ and PPARα. It inhibits the ERK/JNK/Smad/NF-κB signaling pathway and possesses various therapeutic properties.
- Agonist for PPARγ (EC50 of 137.4 nM) and PPARα (EC50 of 546.3 nM)
- Inhibits ERK/JNK/Smad/NF-κB signaling pathway
- Exhibits anti-inflammatory, anti-diabetic, anti-fibrotic, and anti-atherosclerotic properties
- Increases glucose uptake in 3T3-L1 adipocytes and L6 muscle cells
- Inhibits NO generation and pro-inflammatory cytokines in LPS-stimulated BMDMs
- Inhibits TGF-β1-induced expression of α-SMA and fibronectin
- Inhibits PDGF-induced proliferation and migration of vascular smooth muscle cells
MEDCHEMEXPRESS LLC SRI 6409-94 | 127697-58-9 | 99.3% | 379.49 | 1 ML
SRI 6409-94 is an orally active Ro 13-6298 analogue that is teratogenic. It serves as a molecular tool to study the effect of the three-dimensional configuration of retinol on teratogenic activity.
- Causes virgin female outbred Syrian golden hamsters to produce deformed offspring in a dose-dependent manner.
- Leads to significant reductions in mean fetal body weight and in the numbers of ossified skeletal districts.
MEDCHEMEXPRESS LLC HSGN-94 | 2570797-85-0 | 98.8% | 508.51 | 1 ML
HSGN-94 is a potent antimicrobial agent that inhibits lipoteichoic acid (LTA) biosynthesis. It is effective against drug-resistant Gram-positive bacteria, including MRSA and Vancomycin-resistant Enterococci, also inhibiting their biofilm formation. It reduces pro-inflammatory cytokines and shows in vivo efficacy in an MRSA murine wound infection model.
- Potent antimicrobial agent targeting lipoteichoic acid (LTA) biosynthesis.
- Effective against drug-resistant Gram-positive bacteria (MIC values: 0.25-2 μg/mL).
- Inhibits biofilm formation in MRSA and Vancomycin-resistant Enterococci.
- Reduces pro-inflammatory cytokines.
- Demonstrates in vivo efficacy in a murine wound infection model.
- Directly binds to CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase (PgsA).
- Downregulates PgsA expression in *S. aureus*.
- Non-toxic to HaCat cells up to 64 μg/mL.
MEDCHEMEXPRESS LLC Lomitapide | 182431-12-5 | 99.6% | 693.72 | 200 MG
Lomitapide is a potent inhibitor of microsomal triglyceride-transfer protein (MTP) with an IC50 of 8 nM in vitro. Intended for research use only, it undergoes hepatic metabolism via cytochrome P-450 (CYP) isoenzyme 3A4 and interacts with CYP3A4 substrates. It has been shown to reduce plasma concentrations of low-density lipoprotein cholesterol (LDL-C) by more than 50%.
- Target: microsomal triglyceride-transfer protein (MTP)
- IC50: 8 nM (MTP) in vitro
- Metabolism: hepatic metabolism via cytochrome P-450 (CYP) isoenzyme 3A4
- Bioavailability: 7.1% for the 50-mg capsule
- Half-life: 39.7 hours
- Appearance: white to off-white solid
- Powder storage: -20°C for 3 years, 4°C for 2 years
- Solvent storage: -80°C for 2 years, -20°C for 1 year
MEDCHEMEXPRESS LLC Apilimod | 541550-19-0 | 99.8% | 418.49 | 200 MG
Apilimod is a potent IL-12/IL-23 inhibitor, strongly inhibiting IL-12 with IC50s of 1 nM and 2 nM in IFN-γ/SAC-stimulated human PBMCs and SAC-treated monkey PBMCs, respectively. It is also described as a potent and highly selective PIKfyve inhibitor.
- Potent IL-12/IL-23 inhibitor
- Strongly inhibits IL-12 with IC50s of 1 nM and 2 nM
- Potent and highly selective PIKfyve inhibitor
- Inhibits IFN-γ production in human PBMCs
- Reduces severity of experimental autoimmune uveoretinitis (EAU)
- Lowers level of IL-12 p40 in serum without altering body weight in EAU mice
- Effective in Th1 model, with 51%±8% inhibition
MEDCHEMEXPRESS LLC Pomalidomide-amido-C5-PEG2-C6-chlorine | 1835705-69-5 | 98.8% | 594.10 | 50 MG
Pomalidomide-amido-C5-PEG2-C6-chlorine is a derivative of Pomalidomide, intended for research use only. This product is supplied as a white to off-white solid.
- High purity of 98.75%
- Molecular weight of 594.10
- Stable under recommended storage conditions
- Store at 4°C under nitrogen
- For research use only
MEDCHEMEXPRESS LLC Revumenib | 2169919-21-3 | 99.99% | 630.82 | 200 MG
Revumenib (SNDX-5613) is a potent and specific Menin-MLL inhibitor with a binding Ki of 0.149 nM and a cell-based IC50 of 10-20 nM. It is intended for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). For research use only; not for sale to patients.
- Potent and specific Menin-MLL inhibitor.
- Applicable for research in MLL-rearranged acute leukemias (ALL and AML).
- Shows in vivo plasma IC50 of 53 nM.
- Provides significant survival benefit and leukemic control in aggressive MOLM-13 disseminated xenografts in vivo.
MEDCHEMEXPRESS LLC Amino-PEG3-C2-sulfonic acid | 1817735-43-5 | 99.47% | 257.30 | 100 MG
Amino-PEG3-C2-sulfonic acid is a PEG-based PROTAC linker utilized in the synthesis of PROTACs. PROTACs consist of two distinct ligands connected by a linker, with one targeting an E3 ubiquitin ligase and the other targeting the protein of interest. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
- Utilized in the synthesis of PROTACs
- Contains two distinct ligands connected by a linker
- Exploits intracellular ubiquitin-proteasome system
- Selectively degrades target proteins
MEDCHEMEXPRESS LLC Tamoxifen | 10540-29-1 | 99.96% | 371.51 | 200 MG
Tamoxifen is an orally active, selective estrogen receptor modulator (SERM) that blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells. It is a potent Hsp90 activator, enhancing the Hsp90 molecular chaperone ATPase activity. It activates autophagy and induces apoptosis. Tamoxifen can also be dissolved in corn oil for use in inducing gene knockout in CreER transgenic mice.
- Orally active, selective estrogen receptor modulator (SERM)
- Blocks estrogen action in breast cells
- Can activate estrogen activity in bone, liver, and uterine cells
- Potent Hsp90 activator
- Enhances Hsp90 molecular chaperone ATPase activity
- Inhibits infectious EBOV Zaire and Marburg (MARV) with IC50 values of 0.1 μM and 1.8 μM
- Activates autophagy and induces apoptosis
- Can be dissolved in corn oil for gene knockout in CreER transgenic mice
MEDCHEMEXPRESS LLC 2-(2,6-Dioxopiperidin-3-yl)phthalimidine | 26581-81-7 | 99.7% | 244.25 | 200 MG
2-(2,6-Dioxopiperidin-3-yl)phthalimidine (EM-12) is a teratogenic Thalidomide analogue that is more active than Thalidomide and is more stable for hydrolysis. It enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomas. It is an off-white to gray solid.
- Teratogenic thalidomide analogue
- More active than thalidomide
- More stable to hydrolysis
- Enhances 1,2-dimethylhydrazine-induction of rat colon adenocarcinomas
- Off-white to gray solid